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Friday, February 3, 2023

Exercise promotes molecular profile in muscle: research

Health & FitnessExercise promotes molecular profile in muscle: research

A recent paper published in the Journal of Physiology deepens the issue of the youth-promoting effects of exercise on aging organisms, building on previous work done with laboratory mice at their natural age. The end was accessed. Weighted exercise wheel.

The in-depth paper, “A molecular signature defining exercise adaptation to aging and in vivo partial reprogramming in skeletal muscle,” lists a total of 16 co-authors, six of whom are from the University of Associated with Arkansas. Corresponding author is Kevin Morach, assistant professor in the university’s Department of Health, Human Performance and Recreation, and first author is Ronald G. Jones III, Ph.D. student in Morach’s Molecular Muscle Mass Regulation Laboratory.

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For this paper, the researchers compared aged rats that had access to a weighted exercise wheel to rats that had passed out. Epigenetic reprogramming By expressing the Yamanaka factors.

The Yamanaka factors are four protein transcription factors (identified as Oct3/4, Sox2, Klf4 and c-Myc, often referred to as OKSM) that transform highly specialized cells (such as skin cells) back into stem cells. can change to , which is a cell. A smaller and more adaptable state. Dr. Shinya Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this discovery. In the right doses, adding Yamanaka factors to the whole body of mice can improve signs of aging by mimicking the adaptations that are common in more youthful people. Cells

Those that have been reprogrammed by exercise — in the latter case “reprogramming” reflects how environmental stimuli can alter gene accessibility and expression.

The researchers compared the skeletal muscle of mice that were allowed to exercise late in life with the skeletal muscle of mice that had overexpressed OKSM in their muscles, as well as genetically with transgenic mice that were limited to overexpression of Myc in their muscles.

Ultimately, the team determined that exercise promotes a molecular profile consistent with epigenetic partial programming. This means: exercise can mimic aspects of the molecular profile of muscle that has been exposed to Yamanaka factors (thus reflecting the molecular characteristics of more youthful cells). This beneficial effect of exercise may be partially attributed to specific functions of Myc in muscle.

While it would be easy to hypothesize that someday we’ll be able to manipulate the mics in the muscles to achieve the effects of exercise, thereby sparing us the actual effort, Morach cautions that the conclusion is wrong. Have to do.

First, Myc will never be able to mimic all of the downstream effects of exercise throughout the body. It is also the cause of tumors and cancer, so manipulating its expression has inherent risks. Instead, Morach believes that manipulating Mic could be used as an experimental strategy to understand how to restore exercise adaptations in old muscles, which would respond happens. It could potentially also be a means of supercharging the exercise response of astronauts in zero gravity or those confined to bed rest who have only limited exercise capacity. Myc has many effects, both good and bad, so elucidating the beneficial ones could lead to a safer treatment that could work in humans down the road.

Morach sees his research as further validation of exercise as a polypill. “Exercise is the most powerful medicine we have,” he says, and it should be considered a health-improving — and potentially life-extending — treatment along with medicine and a healthy diet.

Morach and Jones’ co-authors at the U of A included Nicholas Green, professor of exercise science, as well as collaborating researchers Fransili Morena da Silva, Seung Kevin Lim and Sabine Khadgi.

This story was published without editing the text from a wire agency feed. Only the title has been changed.

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