A MENINGITIS vaccine generated bactericidal antibodies in Hajj/Umrah vacationers, with stable postvaccination security via 30 days.
Why Older Vacationers Want Safety
Invasive meningococcal illness continues to hold substantial world burden, with greater case fatality charges reported in older adults. Massive mass gatherings can amplify infectious illness danger, and the annual Hajj pilgrimage brings collectively roughly two million folks annually. As a result of quadrivalent meningococcal vaccination is necessary for guests touring to Saudi Arabia for Hajj and Umrah, clinicians advising older vacationers might welcome knowledge targeted on this age group.
What This Research Examined
Investigators performed a Part III, open label research in Turkiye and Lebanon in wholesome adults aged 56 years and older who had been potential Hajj or Umrah pilgrims. Individuals obtained a single dose of a quadrivalent meningococcal tetanus toxoid conjugate vaccine concentrating on serogroups A, C, Y, and W. Immunogenicity was assessed at baseline and 30 days after vaccination utilizing serum bactericidal assays with human complement and rabbit complement. Security outcomes had been collected via 30 days after vaccination, with an extra 14-day reporting window.
Meningitis Vaccine Outcomes After One Dose
Amongst 290 enrolled contributors, day 30 seroprotection charges utilizing human complement, outlined as titers at or above 1:8, had been 82.8% for serogroup A, 92.5% for C, 92.1% for Y, and 83.5% for W. Utilizing rabbit complement with a threshold at or above 1:128, seroprotection charges had been 83.4% for A, 90.0% for C, 94.3% for Y, and 88.9% for W. Human complement geometric imply titers at day 30 had been 32 for A, 132 for C, 126 for Y, and 56.4 for W. Within the per protocol evaluation set, seroresponse charges ranged from 48% to 71.0% throughout serogroups, supporting a sturdy bactericidal antibody response after a single dose.
Security Findings at 30 Days
No security issues had been recognized, and no severe hostile occasions associated to the research vaccine had been noticed. Total, the meningitis vaccine demonstrated an appropriate security profile alongside sturdy immunogenicity in adults aged 56 years and older making ready for Hajj or Umrah journey.
Reference: Dbaibo GS et al. Immunogenicity and Security of Quadrivalent Meningococcal Conjugate Vaccine (MenACYW-TT) in Potential Hajj/Umrah Pilgrims Aged ≥ 56 Years: A Part III, Open-Label Research. Infect Dis Ther. 2026;doi:10.1007/s40121-025-01298-w.
