boy and girl Hearts react differently Stress hormones noradrenaline, according to a recent study published in Science Advances. Human heart conditions such as arrhythmias and Heart failure Also, how different sexes react to certain medications.
The team created a new type of fluorescence imaging system that allows them to use light to see how the mouse heart responds to hormones and neurotransmitters in real time. Rats were exposed to noradrenaline, also known as norepinephrine. Noradrenaline is both a neurotransmitter and hormone associated with the body’s “fight or flight” response. (Also read: Symptoms and warning signs to watch for stress, tips for coping with mental health problems )
The results showed that male and female mouse hearts initially responded similarly after exposure to noradrenaline. However, parts of women’s hearts normalize more quickly than men’s hearts, which creates differences in the heart’s electrical activity.
“The difference in electrical activity we saw in women’s hearts is called repolarization. Repolarization refers to how the heart resets between each heartbeat and has certain types of electrical activity,” said Jessica L. Caldwell, first author of the study. closely related to arrhythmias.” Caldwell is a postdoctoral scholar in the UC Davis School of Medicine Department of Pharmacology.
“We know there are sex differences in the risk of certain types of arrhythmias. The study reveals a new factor that may contribute to the different arrhythmia susceptibility between men and women,” Caldwell said.
Heart disease is the leading cause of death for both men and women in the United States. It accounted for 1 in every 4 men and 1 in 5 women deaths in 2020. Despite the effects on both sexes, cardiology research has mostly been conducted on male subjects.
In this study, the researchers were interested in looking at factors that may contribute to arrhythmias. Arrhythmias are a type of heart disorder where the electrical impulses that control the heartbeat do not work properly. They affect anywhere between 1.5% to 5% of the population.
According to the study’s senior author Crystal M. Replinger, the researchers did not plan to study responses based on sex. But the researchers began to see a pattern of different reactions, which led them to realize that the differences were based on sex.
Riplinger, an electrical and biomedical engineer, is a professor in the Department of Pharmacology. When she started her lab at the UC Davis School of Medicine a decade ago, she used exclusively male animals. This was the norm for most research at the time. But several years ago, he began to include male and female animals in his studies.
“Sometimes the data is similar between the sexes. But if we start to see differences in the data, we look at sex differences first. Using both male and female mice reveals such signs of differences.” have come which we would never have suspected.” “You’re assuming you can’t extrapolate both sexes by studying just one,” said researchers Ripplinger.
She notes that with the current study, it’s unclear what the difference in cAMP and electrical activity might mean. “The response in female mice may be protective — or it may not be. But just documenting that there is a measurable difference in stress hormone response. We hope to learn more in future studies, Ripplinger said.