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Friday, February 3, 2023

Regulating immunological memory may help immune system fight disease: Study

Health & FitnessRegulating immunological memory may help immune system fight disease: Study

Scientists have long worked to better understand it. Immune response Various diseases of the human body such as cancer and inflammatory diseases.

In a recent study at the University of Missouri, Emma Teixeiro, an associate professor at the MU School of Medicine, and her team analyzed how immunological memory—the memory the body’s immune system retains after infection or vaccination— Helps prevent re-infection. Create and maintain roles as well inflammation It plays a role in forming this immunological memory.

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“Our immune system protects us from disease, but it is overwhelming. Complex systems With so many interactions, and if things go unregulated, it can actually play a role in causing disease,” said Teixeiro, who works at the NextGen Precision Health Institute on MU’s campus. can be produced and controlled, particularly by looking at the important role of T cells, as T cells help protect the body from infection and may play a role in attacking cancer.”

Using a mouse model, the researchers created different strains of pathogenic bacteria that increased levels of inflammation through stimulation of interferon genes — or STING — proteins within T cells. While many scientists assumed that this increase in inflammation would result in a stronger immune response and therefore a stronger immune memory, Teixeiro and his team found the opposite: the immunological memory was reduced.

Teixeiro said, “Some scientists believe that STING activation could be targeted to improve cancer vaccines or immunotherapy, so gaining a fundamental understanding of all the interaction mechanisms at play could have unintended consequences. or important to reduce the likelihood of harmful side effects.” “We want to better understand how immunological memory is regulated, which has implications for potential vaccines or immunotherapies that activate T cells in a way that hopefully enhances long-term memory. , so our bodies are immune to disease over time.”

Although his research is basic in nature, Teixeiro’s findings may contribute to the development of more effective treatments to help patients with cancer, chronic obstructive pulmonary disease (COPD), STING-associated vasculopathy with onset in infancy (SAVI), asthma. are capable of and other chronic inflammatory syndromes.

“The acquisition of knowledge is what fuels my curiosity as a scientist,” Teixeiro said. “While there are still more questions to be answered, this research is a small step in the right direction, and I’m proud to be a part of it.” “

“STING regulates T cell memory fitness during infection through a T cell-intrinsic and indoleamine-pyrrole 2,3-dioxygenase (IDO)-dependent mechanism” was recently published in PNAS. Co-authors of the study include Michael Coney, Curtis Pritzl, Rebecca Neuth, Karen Knudsen, Vikas Saxena, Caitlin Guldenpfennig, Diana Gill, Chris Rae, Peter Lauer, Mark Daniels and Desiree Loira.

This story was republished from a wire agency feed without editing the text. Only the title has been changed.

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