Metabolic and bariatric surgical procedure (MBS) presents higher cardiovascular safety than glucagon-like peptide-1 (GLP-1) receptor agonists in people with weight problems and sort 2 diabetes, a 2026 systematic evaluate and meta-analysis has discovered.
Surgical procedure was extra beneficial for each main antagonistic cardiovascular occasions (MACE) and all-cause mortality outcomes.
MBS and GLP-1 Receptor Agonists
MBS and GLP-1 receptor agonists are efficient interventions for weight problems and sort 2 diabetes.
GLP-1 receptor agonist remedy is a longtime therapy possibility that improves metabolic parameters and reduces cardiovascular mortality and hospitalisation charges.
MBS has emerged as a extremely efficient intervention, resulting in remission of diabetes in roughly 31% to 56% of sufferers.
The evaluate in contrast the results of MBS and GLP-1 receptor agonists on all-cause mortality and nonfatal MACE in people with weight problems and sort 2 diabetes.
MACE and All-Trigger Mortality
Practically 20,000 people with weight problems and sort 2 diabetes had been included in evaluation.
MBS was related to a big discount within the danger of MACE and all-cause mortality in contrast with GLP-1 receptor agonist remedy, with a relative danger discount of 52%. Evaluation discovered that MBS produces higher sustained weight reduction in comparison with GLP-1 receptor agonist remedy.
Noticed advantages of MBS prolonged past glycaemic management and weight reduction. Researchers steered this mirrored the multifactorial impression of surgical procedure on metabolic and cardiovascular danger.
Whereas each therapy pathways supply substantial scientific profit, MBS offered a extra pronounced and sturdy danger discount. This was notably obvious in sufferers with longstanding diabetes and better cardiovascular danger.
Therapy Implications
GLP-1 receptor agonists are efficient in decreasing cardiovascular occasions and enhancing metabolic parameters, however (notably long-term) affected person profit seems higher with surgical intervention.
Researchers emphasised that GLP-1 receptor agonist remedy stays important for sufferers who’re ineligible for surgical procedure or looking for non-surgical intervention.
Latest meta-analyses and large-scale cohort research have offered strong supporting proof that MBS is extra beneficial than GLP-1 receptor agonists in decreasing each MACE and all-cause mortality in people with weight problems and sort 2 diabetes.
Reference
Chadwick J et al. Efficacy of metabolic and bariatric surgical procedure in contrast with GLP-1 receptor agonist therapy in stopping mortality and main antagonistic cardiac occasions amongst people with weight problems and sort 2 diabetes: A scientific evaluate and meta-analysis. Obes Surg. 2026;DOI:10.1007/s11695-026-08508-5.
